Luke studied medicine at Oxford University, subsequently switched to a career in finance and held a number of senior management positions at Natwest and Merrill Lynch, and became a senior partner at fund management firm Brevan Howard. He now engages full time with his philanthropic activities in parallel with pursuing his business interests. He is a keen supporter of many organisations associated with Effective Altruism. Luke has sponsored many health care initiatives in developing countries, including national deworming programmes in Burundi and Madagascar. He is based in London.